| Data Details | |
| Disease Name | myocarditis |
| Tissue | heart |
| Database | ArrayExpress |
| Data ID | E-GEOD-6541 |
| Data Type | expression |
| Platform | A-AFFY-25 |
| Species | rattus norvegicus |
| Sample Number | 24 |
| PubMed ID | 18197293 |
| Title | Transcription profiling of rat cardiac injury: a potential link to air pollution mortality? |
| Data Description | "Group 1 received Saline to serve as a control. Group 2 received Mount St. Helen's ash, which does not contain any water-soluble zinc or other metals such that we can delineate any cardiac effect secondary to pulmonary deposition of these particles as these fine mode particles themselves are not likely to translocate to the heart. Group 3 received whole saline suspension of the same fugitive oil combustion particle sample used in the previous study, which contained insoluble components plus water-soluble zinc (Kodavanti et al., 2003; 14.5 Ug/mg zinc) and also a small amount of water-soluble nickel (3.0 uG/mg). Elemental composition of this PM is comparable to Ottawa urban PM (Kodavanti et al., 2003). Group 4 also received same particle sample but at half the dose than group 3. Group 5 received saline-soluble or leachable fraction of PM-HD devoid of any solid material but contained soluble components including zinc and nickel. And, group 6 received zinc sulfate at concentration that was present in groups 3 or 5. This design allowed us to test if cardiac injury in rats was due to leached of zinc or solid particles. There were 4 replicates per treatment group." |
| Keyword | myocardial fibrosis |
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FDRdb: Fibrosis Disease-associated RNAnome database
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